There is an interesting take on self-publishing over here. I may have more on this later but wanted to get the link posted before I forgot.
And I will say, briefly, that I agree with the general point made over there on Futurismic. Economic forces are going to be the thing that make self-publishing a more viable and accepted from of getting your work out there. Just like we are seeing the journalism world change because of economic and technological forces, publishing is going to go through a similar transformation.
The biggest change for the reader will be sniffing out what is quality and what's not. All of our gatekeepers are becoming unnecessary.